I'm unable to send mail please can someone help me fix it

I have suddenly started to get an error message when sending some of my mail it is telling me to go to my "Temporary Directory Settings" as it's unable to send through C:\Users\Tina\AppData\Local\Temp\nsmail.tmp
I have tried unticking my email attachments in my anti virus as I was told to do the last time I had a problem, but to no avail. Please can someone help me fix this and preferably in step by step form ?

I suggest you contact McAfee for instructions. I don't use their product and a year after it started making life hard for Thunderbird users i am sure they can offer constructive workarounds.

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