Icons keep moving to the upper right corner - a Finder relaunch fixes it but only for a short while

I'm having an issue that really irks me and it's very frustrating.  Whenever I open certain programs (ie. iPhoto, Pixelmator, Safari (sometimes)) and I click to the desktop to either drag a file in or drag one out to the desktop, all the icons start gathering in the upper right hand corner on top of the Hard Drive icon.  No matter where I try to drag them, they all snap right back on top of the Hard Drive.  Now, I can stop this by option clicking and holding on the Finder dock icon and selecting Relaunch.  I can also turn "sort by" to none, but I am a little OCD and I like to have my icons snap to a grid.  Here's another vital piece of information.  I use my computer at work on an external monitor connected by the Thunderbolt port (an HP monitor) using a DVI adapter.  However, this occurs with or without using the external monitor.  I noticed this program started happening about 2 months ago after I swapped out hard drives (upgraded size) going from 500GB to 750GB.  I used carbon copy cloner to clone my hard drive as opposed to going with a fresh install.  I'm beginning to think this may have been a bad idea.  I have trashed all the Finder preferences, used Onyx to clear the .DS_stores and other tricks found on the internet.  Does anyone have a concrete way to fix this?  I am baffled with this one.  I've never seen this problem until recently.  Any ideas?

- Restore to factory settings/new iOS device.                       
If still problem, make an appointment at the Genius Bar of an Apple store since it appears you have a hardware problem.
  Apple Retail Store - Genius Bar                                                              
Apple will exchange your iPod for a refurbished one for $99 fr a 16 GB 4G. They do not fix yours.
  Apple - iPod Repair price

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