Illustrator won't open a file after a previous file was closed

First of all, I've been using Illustrator since it first came out (87? 88?) but in all those years, have never encountered the following problem:
After opening and closing an Illustrator file, I can not open any other Illustrator file without quitting the Illustrator app. I get no error messages, the program does not lock up or crash, it simply does nothing. It does not matter if the file I am opening (or the file just worked on) is a newly created one, or an older file, complicated or simple file, 1-color or multi. In other words, it does not seem to be related to the files.
The only way to open a new file after closing a previous file is to QUIT the Illustrator application.
In the old days, if an oddity would occur, deleting the app's pref file usually worked, though it's been years since I've had to do this. Is deleting the pref file still safe/recommended?
Here are some specs:
What I've tried:
Cleared font cache
Repaired disk permissions
Run diagnostics (all clean as a whistle)
System and app specs:
2.66 ghz Intel iMac OS 10.6.8, 4 gig ram
Illustrator CS5 15.0.2
Does anyone have any suggestions? Thank you so much in advance...
Susan

Deleting the prefs is safe, worst that can happen is the setting for scale strokes and effects might get reset.
Reset your preferences.
Cmd-Opt-Ctrl-Shift when restarting AI on a Mac.
Have you tried all the different methods for opening a files, drag and drop to AI on dock, open command.

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