IMac 24" Applications Won't Load...

I have an Intel iMac 24" running 10.6.2 which I bought just before the new models launched. When I boot up the computer everything is just fine, all the apps load and work as they should however as I work throughout the day suddenly apps will just refuse to load. Anything from iTunes to Toast and even I'll problems with Safari.
It almost seems that if I boot up these apps when I start the Mac it might well be fine it's just if I want to start the app later in the day after the computer has been running for some time. Web pages will load in Safari but later on there will be issues with video and Flash sites. The only solution I can see is to force quit then restart the computer and choose the offending app as soon as it boots into the Finder. It's really frustrating if I want to burn a CD in Toast and it won't load and then I have to reboot to get the job done. All the Adobe CS4 apps seem to function fine although I have them set to Open at Login.
I thought I would make a new user and see if that would fix it but the System Preferences app hung when I tried and I had to force quit, I've not tried yet on restart, it might just solve it.
I'm sure others must have had this problem and I'm sorry if I am duplicating a post but I had a look and couldn't find a solution. I have Repaired Permissions and updated to 10.6.2 with the Combo Updater with no joy, it's looking like a reinstall of the OS might be the only resolve. I am using the pre-installed OS and I thought I read somewhere that could have been a problem for some owners.
Please help.
David

Good idea to create a new admin user account to see if the problem recurs there. If it does not, there is something in your normal account that is conflicting. You might open System Preferences Account pane +Login Items+ tab, to check the list of processes that start up automatically at login. If there is anything there you no longer need or that looks suspicious, take it off the list, restart, and see if the problem still recurs. About the only item that is on that list by default is iTunes Helper.

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