IMac performing very slow!

HI all,
I am running an imac with Maverics. I have 4GB of memory with a 2.7 Ghz processor. I have a 3 TB external drive and using Time machine with daily backups. The problem is, for the past few months, the performance of just about everything runs super slow. here are some examples:
1. Upon opening any application or program, I get the Spinning ball
2. I get programs shutting down unexpected all the time. 
3. My mac is set to auto shut down at midnight. Ill wake up in the morning with error m,essages saying certain programs wouldnt let it shut down.
4. I have checked my Internet speed and am getting great upload and download speeds form the server, yet the safari webpages take forever to open.
5. OPening any files takes forever. Almost as if when its trying to read the file to pen it, it gets stuck.
6. Response from any data entry is slow. ie. as I type in a chat box or email, the letters and words are still populating in the box or email but Im done typing.
There are some others happening biut those are the big ones.  Its annoying and very frustrating.  My brother has his imac, same year, and it runs so fast and smooth and I have been trying to get to that point but cannot. Should I bring into a mac store and let them run their program on it and see if my imac is infected or at the very least, they can find the issue?
Thanks for the help.
Regards
Lou

Hardware Information:
          iMac (21.5-inch, Mid 2011)
          iMac - model: iMac12,1
          1 2.7 GHz Intel Core i5 CPU: 4 cores
          4 GB RAM
Video Information:
          AMD Radeon HD 6770M - VRAM: 512 MB
System Software:
          OS X 10.9.2 (13C1021) - Uptime: 0 days 6:11:39
Disk Information:
          ST31000528AS disk0 : (1 TB)
                    EFI (disk0s1) <not mounted>: 209.7 MB
                    Macintosh HD (disk0s2) / [Startup]: 999.35 GB (534.76 GB free)
          OPTIARC DVD RW AD-5690H 
USB Information:
          Apple Inc. FaceTime HD Camera (Built-in)
          Apple Inc. iPhone
          LaCie P'9233 Desktop Drive 3 TB
                    EFI (disk1s1) <not mounted>: 314.6 MB
                    LaCie (disk1s2) /Volumes/LaCie: 3 TB (2.24 TB free)
          Apple Inc. BRCM2046 Hub
                    Apple Inc. Bluetooth USB Host Controller
          Apple Computer, Inc. IR Receiver
          Apple Internal Memory Card Reader
FireWire Information:
Thunderbolt Information:
          Apple Inc. thunderbolt_bus
Kernel Extensions:
          [kext loaded] com.Cycling74.driver.Soundflower (1.5.2) Support
          [kext loaded] com.LaCie.ScsiType00 (1.2.13 - SDK 10.5) Support
          [not loaded] com.jmicron.driver.jmPeripheralDevice (2.0.4) Support
          [not loaded] com.lacie.driver.LaCie_RemoteComms (1.0.1 - SDK 10.5) Support
          [not loaded] com.leapfrog.driver.LfConnectDriver (1.0.6 - SDK 10.0) Support
          [kext loaded] com.oxsemi.driver.OxsemiDeviceType00 (1.28.13 - SDK 10.5) Support
Launch Daemons:
          [loaded] com.adobe.fpsaud.plist Support
          [not loaded] com.gopro.stereomodestatus.plist Support
          [running] com.intego.BackupAssistant.daemon.plist Support
          [running] com.lacie.desktopmanager.service.plist Support
          [not loaded] com.leapfrog.connect.shell.plist Support
          [loaded] com.macpaw.CleanMyMac2.Agent.plist Support
          [loaded] com.microsoft.office.licensing.helper.plist Support
Launch Agents:
          [loaded] com.intego.backupassistant.agent.plist Support
          [loaded] com.lacie.eventsactions.launcher.agent.plist Support
User Launch Agents:
          [loaded] com.adobe.ARM.[...].plist Support
          [loaded] com.adobe.ARM.[...].plist Support
          [loaded] com.citrixonline.GoToMeeting.G2MUpdate.plist Support
          [loaded] com.facebook.videochat.[redacted].plist Support
          [loaded] com.google.keystone.agent.plist Support
          [loaded] com.macpaw.CleanMyMac2Helper.diskSpaceWatcher.plist Support
          [loaded] com.macpaw.CleanMyMac2Helper.scheduledScan.plist Support
          [loaded] com.macpaw.CleanMyMac2Helper.trashWatcher.plist Support
          [not loaded] com.spotify.webhelper.plist Support
          [running] com.zeobit.MacKeeper.Helper.plist Support
User Login Items:
          None
Internet Plug-ins:
          Google Earth Web Plug-in: Version: 5.2 Support
          Default Browser: Version: 537 - SDK 10.9
          Unity Web Player: Version: UnityPlayer version 2.6.1f3 Support
          AdobePDFViewerNPAPI: Version: 11.0.06 - SDK 10.6 Support
          FlashPlayer-10.6: Version: 13.0.0.201 - SDK 10.6 Support
          Silverlight: Version: 5.1.20913.0 - SDK 10.6 Support
          Flash Player: Version: 13.0.0.201 - SDK 10.6 Support
          QuickTime Plugin: Version: 7.7.3
          iPhotoPhotocast: Version: 7.0
          SharePointBrowserPlugin: Version: 14.4.1 - SDK 10.6 Support
          AdobePDFViewer: Version: 11.0.06 - SDK 10.6 Support
          JavaAppletPlugin: Version: 14.9.0 - SDK 10.7 Mismatch! Oracle recommends Java 7 Update 55
Safari Extensions:
          Dashlane: Version: 2.4.0.55923
          ClickToFlash: Version: 2.9.2
          Facebook Photo Zoom: Version: 1.1206.11.1
          MLB.com Toolbar: Version: 1.1
          Searchme: Version: 1.3
          Awesome Screenshot: Version: 1.4.2
Audio Plug-ins:
          BluetoothAudioPlugIn: Version: 1.0 - SDK 10.9
          AirPlay: Version: 2.0 - SDK 10.9
          AppleAVBAudio: Version: 203.2 - SDK 10.9
          iSightAudio: Version: 7.7.3 - SDK 10.9
iTunes Plug-ins:
          Quartz Composer Visualizer: Version: 1.4 - SDK 10.9
User Internet Plug-ins:
          Dashlane: Version: Dashlane 1.0.0 - SDK 10.7 Support
          Move_Media_Player: Version: npmnqmp 071706000001 Support
          CitrixOnlineWebDeploymentPlugin: Version: 1.0.105 Support
          ATTConnectEventEntry: Version: 1.0.3 - SDK 10.6
          WebEx: Version: 1.0 Support
          WebEx64: Version: 1.0 - SDK 10.6 Support
3rd Party Preference Panes:
          Flash Player  Support
          GoPro  Support
          MacFUSE  Support
Time Machine:
          Skip System Files: NO
          Mobile backups: OFF
          Auto backup: YES
          Volumes being backed up:
                    Macintosh HD: Disk size: 930.71 GB Disk used: 432.68 GB
          Destinations:
                    LaCie [Local] (Last used)
                    Total size: 3 
                    Total number of backups: 76
                    Oldest backup: 2013-08-01 04:41:52 +0000
                    Last backup: 2014-04-24 17:43:49 +0000
                    Size of backup disk: Excellent
                              Backup size 3  > (Disk size 930.71 GB X 3)
          Time Machine details may not be accurate.
          All volumes being backed up may not be listed.
Top Processes by CPU:
               7%          PluginProcess
               2%          coreaudiod
               1%          WindowServer
               0%          Safari
               0%          com.apple.WebKit.Networking
Top Processes by Memory:
          233 MB          Safari
          201 MB          PluginProcess
          188 MB          OmniDiskSweeper
          143 MB          firefox
          98 MB          WebKitPluginHost
Virtual Memory Information:
          49 MB          Free RAM
          1.18 GB          Active RAM
          1.14 GB          Inactive RAM
          833 MB          Wired RAM
          1.33 GB          Page-ins
          33 MB          Page-outs

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              [loaded] com.adobe.fpsaud.plist Support
              [invalid] com.Affinegy.InstaLANd.plist
              [loaded] com.microsoft.office.licensing.helper.plist Support
              [running] Jack.plist Support
    Launch Agents:
              [running] com.Affinegy.InstaLANa.plist Support
              [loaded] com.hp.help.tocgenerator.plist Support
    User Launch Agents:
              [failed] com.apple.CSConfigDotMacCert-[...]@me.com-SharedServices.Agent.plist
              [running] com.google.Chrome.framework.plist Support
              [loaded] com.google.keystone.agent.plist Support
              [running] com.spotify.webhelper.plist Support
    User Login Items:
              iTunesHelper
              default.jpg
              Belkin Router Monitor
              EyeTV Helper
              EyeTV
              uTorrent
              Spotify
              Genieo
              RealPlayer Downloader Agent
              HP Product Research
              HP Scheduler
    Internet Plug-ins:
              DirectorShockwave: Version: 12.1.2r152 - SDK 10.6 Support
              Unity Web Player: Version: UnityPlayer version 4.3.7f1 - SDK 10.6 Support
              OfficeLiveBrowserPlugin: Version: 12.2.8 Support
              VLC Plugin: Version: 1.0.5 Support
              Silverlight: Version: 4.0.60531.0 Support
              FlashPlayer-10.6: Version: 13.0.0.214 - SDK 10.6 Support
              QuickTime Plugin: Version: 7.7.1
              Flash Player: Version: 13.0.0.214 - SDK 10.6 Support
              googletalkbrowserplugin: Version: 1.9.2.1599 Support
              npgtpo3dautoplugin: Version: 0.1.43.4 Support
              SharePointBrowserPlugin: Version: 14.3.6 - SDK 10.6 Support
              iPhotoPhotocast: Version: 7.0
              JavaAppletPlugin: Version: 14.9.0 - SDK 10.7 Check version
    Safari Extensions:
              Omnibar: Version: 1.2
    Audio Plug-ins:
              iSightAudio: Version: 7.7.1 - SDK 10.7
    iTunes Plug-ins:
              Quartz Composer Visualizer: Version: 1.3 - SDK 10.7
    User Internet Plug-ins:
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              Google Earth Web Plug-in: Version: 7.1 Support
    3rd Party Preference Panes:
              Flash Player  Support
              Growl  Support
              MacFUSE  Support
    Time Machine:
              Time Machine not configured!
    Top Processes by CPU:
                  47%          Genieo
                  10%          Safari
                   8%          WebProcess
                   2%          WindowServer
                   1%          EyeTV
    Top Processes by Memory:
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              111 MB          Safari
              89 MB          Genieo
              78 MB          WindowServer
              66 MB          Finder
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              1.90 GB          Free RAM
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              277 MB          Inactive RAM
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    EtreCheck version: 2.1.8 (121)
    Report generated March 6, 2015 at 8:25:35 AM CST
    Download EtreCheck from http://etresoft.com/etrecheck
    Click the [Click for support] links for help with non-Apple products.
    Click the [Click for details] links for more information about that line.
    Hardware Information: ℹ️
        iMac (27-inch, Mid 2010) (Technical Specifications)
        iMac - model: iMac11,3
        1 3.2 GHz Intel Core i3 CPU: 2-core
        12 GB RAM Upgradeable
            BANK 0/DIMM0
                2 GB DDR3 1333 MHz ok
            BANK 1/DIMM0
                2 GB DDR3 1333 MHz ok
            BANK 0/DIMM1
                4 GB DDR3 1333 MHz ok
            BANK 1/DIMM1
                4 GB DDR3 1333 MHz ok
        Bluetooth: Old - Handoff/Airdrop2 not supported
        Wireless:  en1: 802.11 a/b/g/n
    Video Information: ℹ️
        ATI Radeon HD 5670 - VRAM: 512 MB
            iMac 2560 x 1440
    System Software: ℹ️
        OS X 10.10.2 (14C109) - Time since boot: 3 days 23:34:34
    Disk Information: ℹ️
        ST31000528AS disk0 : (1 TB)
            EFI (disk0s1) <not mounted> : 210 MB
            Macintosh HD (disk0s2) / : 999.35 GB (636.35 GB free) - 523 errors
            Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
        OPTIARC DVD RW AD-5680H 
    USB Information: ℹ️
        HP Officejet Pro 8500 A910
        Apple, Inc. Keyboard Hub
            Apple, Inc Apple Keyboard
        Apple Computer, Inc. IR Receiver
        Apple Inc. Built-in iSight
        Hewlett-Packard HP LaserJet Professional P1606dn
        Neat NeatConnect Scanner
        Apple Inc. BRCM2046 Hub
            Apple Inc. Bluetooth USB Host Controller
        Apple Internal Memory Card Reader
    Gatekeeper: ℹ️
        Mac App Store and identified developers
    Kernel Extensions: ℹ️
            /System/Library/Extensions
        [not loaded]    com.marvell.kext.USBGenericPrinterClass (1.0.0) [Click for support]
    Launch Agents: ℹ️
        [loaded]    com.carbonite.launchd.carbonitealerts.plist [Click for support]
        [running]    com.carbonite.launchd.carbonitestatus.plist [Click for support]
        [running]    com.citrixonline.GoToMyPC.LaunchAgent.plist [Click for support]
    Launch Daemons: ℹ️
        [running]    com.carbonite.launchd.carbonitedaemon.plist [Click for support]
        [running]    com.citrixonline.GoToMyPC.CommAgent.plist [Click for support]
        [loaded]    com.microsoft.office.licensing.helper.plist [Click for support]
        [loaded]    com.oracle.java.JavaUpdateHelper.plist [Click for support]
        [loaded]    com.roamingclient.cell.mac.tm.roamingclient.plist [Click for support]
        [running]    com.tmobile-rocket20.zerocd.plist [Click for support]
    User Launch Agents: ℹ️
        [loaded]    com.adobe.ARM.[...].plist [Click for support]
        [failed]    com.citrixonline.GoToMeeting.G2MUpdate.plist [Click for support] [Click for details]
        [loaded]    com.google.keystone.agent.plist [Click for support]
        [running]    com.hp.printerAgent.plist [Click for support]
    User Login Items: ℹ️
        None
    Internet Plug-ins: ℹ️
        JavaAppletPlugin: Version: Java 7 Update 51 Check version
        FlashPlayerDebugger-10.6: Version: 11.2.202.235 [Click for support]
        AdobePDFViewerNPAPI: Version: 10.1.13 [Click for support]
        AdobePDFViewer: Version: 10.1.13 [Click for support]
        Flash Player: Version: 11.2.202.235 Outdated! Update
        Default Browser: Version: 600 - SDK 10.10
        QuickTime Plugin: Version: 7.7.3
        SharePointBrowserPlugin: Version: 14.4.8 - SDK 10.6 [Click for support]
        Silverlight: Version: 5.1.20513.0 - SDK 10.6 [Click for support]
        DirectorShockwave: Version: 11.5.9r620 [Click for support]
        iPhotoPhotocast: Version: 7.0 - SDK 10.8
    User internet Plug-ins: ℹ️
        CitrixOnlineWebDeploymentPlugin: Version: 1.0.105 [Click for support]
    3rd Party Preference Panes: ℹ️
        Carbonite  [Click for support]
        Flash Player  [Click for support]
        GoToMyPC Preferences  [Click for support]
        Growl  [Click for support]
    Time Machine: ℹ️
        Auto backup: YES
        Volumes being backed up:
            Macintosh HD: Disk size: 999.35 GB Disk used: 363.00 GB
        Destinations:
            Taylor Technology Time Caps [Network]
            Total size: 2.00 TB
            Total number of backups: 91
            Oldest backup: 2014-01-13 06:38:23 +0000
            Last backup: 2015-03-06 14:07:22 +0000
            Size of backup disk: Adequate
                Backup size 2.00 TB > (Disk used 363.00 GB X 3)
    Top Processes by CPU: ℹ️
            81%    CarboniteDaemon
             4%    WindowServer
             3%    Neat
             1%    HP Scanner 3
             0%    Microsoft Word
    Top Processes by Memory: ℹ️
        3.05 GB    Neat
        1.46 GB    CarboniteDaemon
        232 MB    Microsoft Word
        232 MB    Finder
        219 MB    WindowServer
    Virtual Memory Information: ℹ️
        327 MB    Free RAM
        4.78 GB    Active RAM
        4.18 GB    Inactive RAM
        1.15 GB    Wired RAM
        125.62 GB    Page-ins
        298 MB    Page-outs
    Diagnostics Information: ℹ️
        Feb 12, 2015, 10:18:58 AM    /Library/Logs/DiagnosticReports/Kernel_2015-02-12-101858_[redacted].panic [Click for details]

    Matt ... got it done, recovery repair said Hard Drive OK.  Re-ran EtreCheck report attached ... still having the same issues.  Everything is fully backed up to Carbonite and Time Machine ... let me know if you see other conflicts or if it is the hard drive I will work to get it repaired.
    Thanks.
    EtreCheck version: 2.1.8 (121)
    Report generated March 6, 2015 at 9:28:28 AM CST
    Download EtreCheck from http://etresoft.com/etrecheck
    Click the [Click for support] links for help with non-Apple products.
    Click the [Click for details] links for more information about that line.
    Hardware Information: ℹ️
        iMac (27-inch, Mid 2010) (Technical Specifications)
        iMac - model: iMac11,3
        1 3.2 GHz Intel Core i3 CPU: 2-core
        12 GB RAM Upgradeable
            BANK 0/DIMM0
                2 GB DDR3 1333 MHz ok
            BANK 1/DIMM0
                2 GB DDR3 1333 MHz ok
            BANK 0/DIMM1
                4 GB DDR3 1333 MHz ok
            BANK 1/DIMM1
                4 GB DDR3 1333 MHz ok
        Bluetooth: Old - Handoff/Airdrop2 not supported
        Wireless:  en1: 802.11 a/b/g/n
    Video Information: ℹ️
        ATI Radeon HD 5670 - VRAM: 512 MB
            iMac 2560 x 1440
    System Software: ℹ️
        OS X 10.10.2 (14C109) - Time since boot: 0:2:41
    Disk Information: ℹ️
        ST31000528AS disk0 : (1 TB)
            EFI (disk0s1) <not mounted> : 210 MB
            Macintosh HD (disk0s2) / : 999.35 GB (643.46 GB free) - 21 errors
            Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
        OPTIARC DVD RW AD-5680H 
    USB Information: ℹ️
        HP Officejet Pro 8500 A910
        Apple, Inc. Keyboard Hub
            Apple Inc. iPhone
            Apple, Inc Apple Keyboard
        Apple Inc. Built-in iSight
        Apple Computer, Inc. IR Receiver
        Hewlett-Packard HP LaserJet Professional P1606dn
        Neat NeatConnect Scanner
        Apple Inc. BRCM2046 Hub
            Apple Inc. Bluetooth USB Host Controller
        Apple Internal Memory Card Reader
    Gatekeeper: ℹ️
        Mac App Store and identified developers
    Kernel Extensions: ℹ️
            /System/Library/Extensions
        [not loaded]    com.marvell.kext.USBGenericPrinterClass (1.0.0) [Click for support]
    Launch Agents: ℹ️
        [loaded]    com.carbonite.launchd.carbonitealerts.plist [Click for support]
        [running]    com.carbonite.launchd.carbonitestatus.plist [Click for support]
        [running]    com.citrixonline.GoToMyPC.LaunchAgent.plist [Click for support]
    Launch Daemons: ℹ️
        [running]    com.carbonite.launchd.carbonitedaemon.plist [Click for support]
        [running]    com.citrixonline.GoToMyPC.CommAgent.plist [Click for support]
        [loaded]    com.microsoft.office.licensing.helper.plist [Click for support]
        [loaded]    com.oracle.java.JavaUpdateHelper.plist [Click for support]
        [loaded]    com.roamingclient.cell.mac.tm.roamingclient.plist [Click for support]
        [running]    com.tmobile-rocket20.zerocd.plist [Click for support]
    User Launch Agents: ℹ️
        [loaded]    com.adobe.ARM.[...].plist [Click for support]
        [loaded]    com.citrixonline.GoToMeeting.G2MUpdate.plist [Click for support]
        [loaded]    com.google.keystone.agent.plist [Click for support]
        [running]    com.hp.printerAgent.plist [Click for support]
    User Login Items: ℹ️
        None
    Internet Plug-ins: ℹ️
        JavaAppletPlugin: Version: Java 7 Update 51 Check version
        FlashPlayerDebugger-10.6: Version: 11.2.202.235 [Click for support]
        AdobePDFViewerNPAPI: Version: 10.1.13 [Click for support]
        AdobePDFViewer: Version: 10.1.13 [Click for support]
        Flash Player: Version: 11.2.202.235 Outdated! Update
        Default Browser: Version: 600 - SDK 10.10
        QuickTime Plugin: Version: 7.7.3
        SharePointBrowserPlugin: Version: 14.4.8 - SDK 10.6 [Click for support]
        Silverlight: Version: 5.1.20513.0 - SDK 10.6 [Click for support]
        DirectorShockwave: Version: 11.5.9r620 [Click for support]
        iPhotoPhotocast: Version: 7.0 - SDK 10.8
    User internet Plug-ins: ℹ️
        CitrixOnlineWebDeploymentPlugin: Version: 1.0.105 [Click for support]
    3rd Party Preference Panes: ℹ️
        Carbonite  [Click for support]
        Flash Player  [Click for support]
        GoToMyPC Preferences  [Click for support]
        Growl  [Click for support]
    Time Machine: ℹ️
        Auto backup: YES
        Volumes being backed up:
            Macintosh HD: Disk size: 999.35 GB Disk used: 355.88 GB
        Destinations:
            Taylor Technology Time Caps [Network]
            Total size: 2.00 TB
            Total number of backups: 91
            Oldest backup: 2014-01-13 06:38:23 +0000
            Last backup: 2015-03-06 14:07:22 +0000
            Size of backup disk: Adequate
                Backup size 2.00 TB > (Disk used 355.88 GB X 3)
    Top Processes by CPU: ℹ️
            25%    CarboniteDaemon
             3%    WindowServer
             2%    systemstatsd
             1%    launchd
             0%    HP Scanner 3
    Top Processes by Memory: ℹ️
        129 MB    CarboniteDaemon
        103 MB    ocspd
        77 MB    Safari
        52 MB    Dock
        39 MB    mds_stores
    Virtual Memory Information: ℹ️
        9.94 GB    Free RAM
        1.48 GB    Active RAM
        539 MB    Inactive RAM
        922 MB    Wired RAM
        1.01 GB    Page-ins
        0 B    Page-outs
    Diagnostics Information: ℹ️
        Mar 6, 2015, 09:24:22 AM    Self test - passed
        Feb 12, 2015, 10:18:58 AM    /Library/Logs/DiagnosticReports/Kernel_2015-02-12-101858_[redacted].panic [Click for details]

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