Imac wakes from sleep but is unresponsive

My i5 imac with 10.6.8 has recently and randomly started being unresponsive upon waking from sleep. it does not happen all of the time and I can't find a combo of apps or other events that cause the issue to happen. it's only been in the last few weeks and the only changes I've made are the installation of spotify, update of flash and update of pdf reader.
When my imac is asleep I can press a key on the keyboard or move the magic mouse and the screen wakes right up. the mouse cursor moves around the screen but nothing is clickable and no keyboard commands work. if my laptop is connected via disk sharing I can continue to access the files, it's like everything is fine but I can't give input. the dock doesn't pop up and I can't force quit anything. I ran disk utility and it suggested I restart from the dvd and repair the disk. after doing that the HD continues to test fine, when I verify it there are no errors or other things that need fixing. I've reset NVRAM several times and the problem persists. a hard reset is my only way to regain control and then the computer will work fine for anywhere from hours to days. Everything I search for seems to be a different version sleep issues. I have no video distortion, no other problems. can anyone help me out?
thanks!!
Mark

Howdy there Mark,
I would suggest a few steps here.
First I would start with resetting the SMC on the computer with this article Intel-based Macs: Resetting the System Management Controller (SMC) found here http://support.apple.com/kb/HT3964
Resetting the SMC for Mac Pro, Intel-based iMac, Intel-based Mac mini, or Intel-based Xserve
Shut down the computer.
Unplug the computer's power cord.
Wait fifteen seconds.
Attach the computer's power cord.
Wait five seconds, then press the power button to turn on the computer.
Then reset the PRAM if the issue is not resolved:
About NVRAM and PRAM
http://support.apple.com/kb/ht1379
I would also perform a safeboot to troubleshoot this as well.
Mac OS X: What is Safe Boot, Safe Mode?
http://support.apple.com/kb/HT1564
All the very best,
Sterling

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