In Design CC crashes on everything having to do with a file

I have a 48 page document, that was completely finished - by the way, that yesterday was working fine.  This morning I go to open it and it crashes whenever I try to do anything...e.g replace a photo, output to an earlier CS file, etc.  Have called tech support and downloaded all the plug-in bug fixes...nothing has worked.  Have not uninstalled/re-installed...but have a feeling that won't make a difference.
Anyone experiencing something similar?

Hi Peter, thanks for the info - I'm up against a deadline and this has nearly brought me to tears (decided to open a bottle of wine, instead).  Okay, so yes - with tech support I did install the patches earlier, didn't help.
Do you happen to know whether it's an issue with the fonts used in the document or just all the fonts I have in my fonts folder?  I probably have less than a dozen fonts used in the document - but they're pretty standard one's like Myriad and Garamond, so doubt that would those be the issue?  I really would like to avoid having to recreate the entire magazine…  Literally finished it last night.

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