InDesign CC fails to startup, CC Desktop will not install

One of the Macs will not start up InDesign. It gives the error message that we have insufficient permissions to access the preferences folder. We have made the preferences folder read/write for all and applied this to all enclodsed folders, but no change. Added to this the CC desktop will not install; I have changed the OOBE folder to OOBE_old and again no change. Does anyone have any clues as this is beginning to seriously hamper production. Thanks.

Link for Download & Install & Setup & Activation problems may help
-Chat http://www.adobe.com/support/download-install/supportinfo/
OR
-http://helpx.adobe.com/creative-cloud/kb/error-downloading-cc-apps.html
-http://forums.adobe.com/community/download_install_setup
-http://helpx.adobe.com/creative-cloud/kb/troubleshoot-cc-installation-download.html
-http://helpx.adobe.com/x-productkb/global/errors-or-unexpected-behavior-websites.html
-http://helpx.adobe.com/creative-cloud/kb/unknown-server-error-launching-cc.html
-Server won't connect https://forums.adobe.com/thread/1233088

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