Indesign CS3 Locks up (Not Responding) In Windows Vista 64 bit

Fully updated InDesign CS
Fully Updated Windows Vista 64 bit
90% of the time it locks up right away upon opening any file. When I create a file from scratch it locks up as I try to save or export as a pdf. Basically I can't touch anything except for the settings under Edit.
Not sure how to fix it. I'm a graphic designer, and it's been like this since I reformatted 3 weeks ago, can't accept any projects until I get it up and running again.
Any ideas? Any advice is greatly appreciated!
Thanks
Mike

The subject line says CS3 and the body copy says CS?
Which is it. Note: CS3 is version 5 and CS is version 3.
CS3 is the earliest version supported under Vista.
Bob

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From: [email protected]
To: [email protected]
Subject: Adobe Reader Does Not Respond in Windows 8
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