InDesign CS6 will not retain preferences

One of my users was recently upgraded from CS5 to Design and Web Premium CS6.  The first issue is that the InDesign program crashes for no apparent reason from time to time.  Secondly, the InDesign program will not retain any preferences.  If the program crashes and is restarted, the preferences are lost.  Also, if the program is closed normally and reopened, the preferences are lost.  This started happening about one month ago and prior to that, there were no problems. 
I have searced the forums and internet for a solution and while I've been able to find similar issues with other users, I cannot find a resolution.  Re-installaiton of the program has not produced a resolution.  Can anyone assist with this frustrating problem.

I'm sorry Pete...I didn't quite get your response.  Can you reboot into safe mode, disable all drivers, turn off your virus protection, uninstall the latest service pack and then reinstall it, check your fonts because bad fonts can cause problems in getting responses through.
Pete...I don't disrespect you. I DON'T EVEN KNOW YOU.  I'm sure that your intentions are always legit and that you truly TRY to help people.  My only issues are that I came her for help and would rather have a dozen people shrug their shoulders and say "IDUNNO" rather than getting the same old questions about drivers, service packs, virus protection, firewalls or first born male childs birthdate.  While I may have been aggressive in looking for a solution....I did find your responses to be a bit patronizing and belittling.  I do not disrespect you.
A different philosophy?  ABSO-FREAKING-LOUTLEY!!!  I'm more of a "fix the problem guy".  Forget the amputation...put the poor ******* out of his misery and perform a Frankenstein ritual to bring him back to life (My analogy for a quick re-image from my deployment server).  Fortunately for me, I was able to solve the issue by simply recreating a user profile.
Once again, thanks Pete for you response.

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