Installed 106.3 with Combo Update but Mail won't open at all

Never saw this happen before. Mail.app won't open. Anyone else seeing this?

Exactly the same problem here. I ended up using a TC Restore and even then had to reload 10.6 from DVD, download 10.6.1 and then 10.6.2.
I won't be going down the 10.6.3 route again! I need Mail to run!
Has Apple shot itself in the foot?
Kind Regards
Hugh

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