Installing eSATA cards in 2010 Mac Pro

I see from the Apple website that it lists the 2010 Mac Pro as having:
One PCI Express 2.0 x16 slot
Two PCI Express 2.0 x4 slots
Would these 3 slots be the free, open slots that I appear to see sitting just above my video card - or is the video card plugged into one of these?
My real question here is that I ordered 2 eSATA cards from OWC and am curious if it matters which of the free PCI Express slots I install the cards into.

Yes, those are open and if you use a double wide 2nd graphic card, that will block one of the 4x slots.
Some 8x cards (SAS/SATA/FC RAID cards do best in 16x slots.
Which card and how you intend to use are of more importance probably. Not all cards work for a given use, and whether you want to avoid Port Multiplier cases.
There is a lot of information covered on MPG:
http://macperformanceguide.com/index_topics.html
http://www.apple.com/support/macpro

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    Power Pig wrote:
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    I was talking about this.
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    You are due for a new build or pre-built, most definitely.
    you should be able to hit score of 14k on 6-core w/o trouble.
    And for what you can get for £1799 - £2099 I think you could build one, but start with quality parts and go with a solid foundation that will be supported for years. As long as you don't need OS X as it stands.
    the mac pro use to shine when it came to dual processor setups. Custom built dual PCs can be another matter, and not for faint of heart.
    Choose current socket support, processor, and motherboard and you really are set for years and can upgrade from there.
    Take a look at this for a start:
    http://www.amazon.com/ASUS-LGA-2011--X79-Motherboards/dp/B006L6ZIU4/

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