Integration of CUCM 8.5 with Microsoft Lync 2010 issues

Hi All,
We have integrated CUCM 8.5 with Microsoft Lync 2010 (both Mediation and front end server on Virtual machine on same location) on lab environment, and which is working perfectly on both ways (Two way calls with no issues). But, when we tried configuring the same on live environment, we have no two ways calling between Lync client and IP phone endpoints. Our Mediation and front server are in U.S and CUCM 8.5 cluster are in India and lync clients are in India region, connected via MPLS link and all the traffic ports are open. The following are the configuration on both sides:
CUCM side:
•- Created Direct SIP trunk with MTP enabled.
•- Assigned Mediation server IP address to Port 5068.
•- TCP enabled
LYNC Side:
•- Followed the steps from Cisco Lync integration document through cisco website.
Are they any other configuration requires, when the servers are in different location?

You configure the CUCILync client as a shared line.  You then tell the CUCILync client what to control either the desk phone or use the CUCILync client itself.  When CUCILync controls the phone it is not registered in CUCM.  CUCILYNC will still give a screen POP when the desk phone is controlled.

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