Invalid drive error - installing a new version of iTunes

When I first installed iTunes a few years ago, it was originally loaded on a portable hard drive called (F:). I have everything transferred onto a new hard drive called (E:).
However, when prompted by iTunes to download the latest version, I download the iTunes setup successfully, but when I try to open and run it, I keep getting the error 'Invalid Drive (F:).
I want to avoid deleting and reinstalling iTunes all together - do I have any other choices?
Thanks.

I'm having exactly the same problem so if someone can advise it would be much appreciated.

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