Invalid FROM/SENDER addresses?

What is everyone's thoughts/expierence with trying to enforce valid FROM e-mail addresses? I work for an organization of 16,000 users and currently any IT person can write a script to send e-mail FROM any address even an invalid one. The problem that I'm seeing is now this e-mail has no valid place to bounce back to if it fails to deliver for whatever reason. This has caused everything from thousands of e-mails queued up on our appliances that have no place to deliver to, to the IT person not being able to track down a simple delivery failure because it couldn't come back to their mailbox. The big concern that I have is when e-mail leaves our environment with an invalid FROM address, I'm guessing this can't be good for our sender reputation. Any thoughts? Do I try to enforce valid FROM/Sender e-mail addresses?
Thanks and LONG LIVE THE NATION!

Just checking to see if there has been any further developments on this topic from CISCO/IronPort.
I took over an installation that had 200+ domains that we hosted and I'm narrowing that down to one.  Due to the number of e-mail domains we had the IronPort appliances were basically originally configured to allow anything from our internal network to be delivered.  Now that we have consolidated down to only a handful of e-mail domains I am starting to clean this up. 
Currently I am just using mail polices that does a LDAP lookup on the sender address and then in a policy following that I use a content filter on the Sender header.  Any sent e-mail that misses the LDAP lookup is invalid and then I have a content filter on the following policy looking for that same domain.  If the content filter has any hits the sender must not have been in the LDAP and thus invalid.
I also have some e-mail domains that are sending e-mail via my appliances that I don't have access to LDAP for and I guess I could use the Envelope Sender matches dictionary content method.
The challenge that I'm starting to find though is if someone has 'forwarding' turned on an account.  Still working to find a way to resolve that.
Anyway, wanted to send the discussion to the top and see if anyone else out there was fighting the good fight. 
Long live the Nation!
Jason

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