IPhone 3G won't show up in iTunes but does in System Profiler

So early today, when I was clicking check for updates every half hour like everyone else waiting for 3.0 to go live I had this crop up. I had quit iTunes, unplugged the iPhone (2.2.1) and when I plugged it in.. nothing.. didn't even get the chirp from the iPhone showing it was charging, it won't auto-launch iTunes and if Itunes is open it won't chow up.
- Tried a original iPhone cord and same thing,
- used a Apple wall charger and the phone chirped and showed it was charging
- restarted the Mac Pro and the iPhone, still nothing
- took the original cord and phone (still v2.2.1) to a iMac in another room and it worked perfectly.
- used the iMac to update to iPhone 3.0 software
- went back to the Mac Pro and it charges now, shows up in System Profiler, nothing else
Latest version of all the software, including 2.2.1 (and then 3.0) on the iPhone. All the updates on the Mac Pro.
Hints short of nuking my iTunes completely (and all my rankings, etc in my music)?

Oh, one more thing, I have reset PRAM if that matters.

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