IPhone 4s won't Sync

My iPhone 4s won't sync with my Macbook Pro.
I have:
Macbook Pro running Mac OS 10.5.8
iTunes 10.6.3 (i.e. latest update - which hasn't had an issues apart from syncing).
I just updated the iPhone to iOS6 (thought it wasn't syncing before the update either).
I also just uninstalled and reinstalled iTunes 10.6.3
I tried 3 different USB sync cables. Still not syncing.
Do I really have to update my Mac OS (to 10.6.8 or 10.7) in order to sync my phone ? I thought as long as you have iTunes 10.6.3 you're ok...
Is there a way to update to Mac OS 10.6.8 (or later) without wiping the hard drive and doing a new install?..
thanks

Its telling me it cannot read or find the podcasts I'm trying to sync. I can hear them through my computer though.

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