Iphone 6 plus will not connect to itunes through my computer

Got the new Iphone 6 Plus and for some reason when I plug into computer (which should normally automatically start up iTunes) it does not!!!  Can anyone help me in setting this up.   I played around with it for some time, and it will opened up and I did manage to back up and sync the iphone 6+ & computer.  But it will not do it again.  I have the latest ITunes and have done a restart.  Any help out there???  Thanks 

There might be reasons to use both methods:
Use iCloud and iTunes Backup together
For an extra level of backup for your data, you can use iCloud Backup and iTunes Backup together.
Using iCloud Backup doesn't disable iTunes Backup completely; it just turns off Automatic Backups via iTunes. You can trigger a manual iTunes Backup whenever you want to create a new one.
If you're using iCloud and iTunes Backup together and you want to speed up your iCloud Backup and restore, you can save iCloud storage by turning off iCloud Backup for very large data types. For example, in iOS 8 with iCloud Photo Library beta turned off (or in an earlier version of iOS), if you have a 15 GB photo library on your iPhone, you might not wish to back it up to iCloud because it's already being manually backed up to iTunes.
copied from Choosing an iOS backup method (Should I use iTunes or iCloud to back up my iOS device?)

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