IPhone back up corrupted/Cannot back up IPhone 3gs

Hello chaps. My fiance has been unable to back up her IPhone 3gs recently in preparation of upgrading to IOS 5.
In the first instance she received an error message saying " An error occurred while backing up this IPhone (-5000)" , after which she decided to install the latest version of ITunes and try again. Unfortunately this has done nothing to help and after following advice from the apple which told her to delete previous backups and start again she found no backups to delete.
  Today she thought she would try backing up the IPhone again on the off chance it was a glitch however this error message has now come up (See picture below).
If anyone has any ideas as to what she could do to remedy this problem both she and I would be grateful.
Many thanks people !

Adition to main post the steps that have been taken with regards to this issue.
No1 Initially upgraded Itunes to 10.5 resulting in her computer freezing and needing a hard boot.
No2 After hard boot she plugged in the Iphone 3gs and tried to sync but got an error msg (-5000)
No3 Next day tried again but this time had "Corrupt back up msg" (as above image)
No4 Followed Apples online directions for removing corrupt back ups and deleted them all.
No5 After experiencing the same problem followed Apple support and used the "Repair" function for Itunes.
No6 After this got to step one of back up but it stuck their for 6 hrs until she gave up.
No7 Removed Itunes via Apples online directions and then downloaded (again) 10.5 and installed it.
No8 Apple store doesnt load but the apps update fine (no drop in internet connection)
No9 Iphone still wont sync, not even getting past the initiation stage !
Please help anyone who knows any other steps we could try ??

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