IPhone is not being recognised by iTunes and won't sync

A few days my iPhone randomly froze so I had to do a hard reset. Then when I plugged it into my laptop and tried to sync it, it said The required file could not be found. I pressed ok and then another box came up with something along the lines of iPhone could not be synced, error -6999.
So I unplugged and plugged back in and a message came up saying "iTunes cannot read the content of the iPhone. Go to the summary tab in iPhone preferences and click restore to restore this iPhone to its factory settings". So i did this, restored everything to factory and then tried to re-sync with my computer. Then exactly the same error came up as before (file cannot be found, iPhone doesnt sync). And the circle goes on and on and on.
I've tried restarting, re-installing itunes. I think iTunes is working though because I can still sync my nano with no trouble. Any ideas? Because this is really annoying.
Cheers, Skiddz

I'm having the same problem... just got a new iPhone 3GS in addition to the older 3G model. I need to synch them both with home (music, photos, videos etc. master) and work computers (Contacts, Calendar master).
This worked no problem on the older 3G model, the 3GS synched with my home computer but my work once I get the following message: "iTunes cannot read the content of the iPhone. Go to the summary tab in iPhone preferences and click restore to restore this iPhone to its factory settings".
I've tried re-starting both iPhone and computer, un-installing and re-installing iTunes / QuickTime / Apple Mobile Device Manager etc.; different USB ports etc. and still the problem exists...
Please help.

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