IPhone suddenly will not sync and locks up iTunes

For a little over 2 weeks now, my iPhone will not sync properly with iTunes. I'll plug in my iPhone and it will instantly lock up iTunes, with the spinning rainbow and all. After awhile, iTunes will start working again, but will be extremely sluggish. If I try to sync the iPhone, it just does a neverending sync, and won't actually work. The phone will show up in iPhoto, but won't show up on my desktop. I've tried reinstalling iTunes over the current version, I've tried different USB ports, different USB cables ... I just cannot figure this out!! Help!

The iPhone does not show up on your desktop regardless - even with manually manage music and video selected for your iPhone sync preferences. The iPhone does not support disk mode.
You are connecting direct to a USB port on your Mac, and not via a USB hub - with connecting to an available USB port on your keyboard or monitor considered a hub?
Does your Mac have USB 2.0 ports, or 1.1?
Long shot for this particular problem, but as a first step, try reseting the sync history on your Mac, which is done via iSync preferences with the iSync application.
After selecting Reset Sync History, restart your Mac and try again.
Have you tried resetting your iPhone?

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