IPhone won't turn off and won't sync even after I plug in my computer.

My iPhone started acting odd after my husband updated it to iOS5.  It started with when I touch the apps, it responded with delay.  Today, when I want to check my email.  The app just simply not responding to any touch on the screen.  I tried to turn off to restart, but it won't turn off.  So I plug in my computer try to sync see if that can somehow makes it "budge".  I successfully upload the new photos from iPhone to my MacBookPro, but after that, it won't "sync".  The "sync" bottom on the itune page stay "gray".  I cannot click on it.  What should I do?

Try a Reset...
Press the sleep/wake button & home button at the same time, keep pressing until you see the Apple logo, then release the buttons..
http://support.apple.com/kb/ht1430
The Basic Troubleshooting Steps are:
Restart..  Reset..  Restore from Backup...  Restore as New..
Backing up, Updating and Restoring
http://support.apple.com/kb/HT1414
Backup and Set Up as New Device
http://support.apple.com/kb/HT4137

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