IPhones won't mount in iTunes - Mac restart needed

I'm having the problem long described in iOS: Device not recognized in iTunes for OS X - Apple Support.
Our iPhones stop being recognized by iTunes 12. I've followed the recommended fixes, and the only thing that works consistently is to reboot my Mac. Logging out doesn't help. Switching cables doesn't help and when it happens it affects all devices, not one particular device. It seems to happen after I get "iphone no longer connected' messages.
It's darned frustrating. It doesn't seem to be an extremely common issue, so I wonder if there's a hardware problem somewhere (Mac motherboard? USB hub?).
I also suspect bugs related to 'Trust this Computer' but resetting Trust settings didn't help.
Anyone have ideas on how to debug?
Only thing I can think of is to try going without the hub for a while and switch to wifi sync and separate charger.
Any other ideas?

Sounds like this thread is about the same problem:
Re: itunes 12 will not recognize iphone
Alleged cause is a bug - usbmuxd isn't closing its file descriptors. After 2-3 days errors pile up, typically with recurrent "Trust This Computer?" loops (which is what I see). In this case the "Trust this" is a misleading message related to usbmuxd locking sockets.
Killing usbmuxd process in activity monitor didn't fix the bug for me, I still had to reboot. I noticed though that I had a Tech Tools Pro daemon running that I didn't expect and I have uninstalled that. I'll try killing ubsmuxd next time this happens.
We very much need iTunes 12.0.2+

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I have a 20gb iPod that's nearly 3 years old & my PC is running Windows XP Professional with SP2. And I've got the latest version of iTunes (7.4.3).
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IPhones won't mount in iTunes - Mac restart needed

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