Is Adobe CS4 compatable with a mac 10.5.8?

I'm having troubles opening up Ai with my Mac 10.5.8. I open it and click File>New and the screen is still blank with occasional pop-ups about "plug-ins." Not quite sure what to do. Should I uninstall?

Maybe something went wrong when installing
So you should uninstall, run the clean script and then reinstall:
Adobe - Adobe CS4 Clean Script

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