Is anyone else having this problem?

I can open itunes once but if I close it for any reason I have to shut down my computer and restart it before itunes will open again

Follow this article to create another User Account and test out if you are still getting this problem. If you don't see this problem under new user, go back to your original user and follow same article under USER SPECIFIC TROUBLESHOOTING to troubleshoot.
iTunes for Windows Vista or Windows 7: Troubleshooting unexpected quits, freezes, or launch issues
http://support.apple.com/kb/TS1717

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