Is it harmful to always leave several programs open and never shutting computer down?

I never shut down my computer and simply let it to sleep.  I also let it sleep and leave several programs like illustrator open all the time.  Is this good for the computer or should I be closing down applications regularly?

If your system is powered through an uninterruptible power
source, there is no issue at all.
If not, there is always the possibility of something going bad
should a power outage occur.  This is true whether apps are
open or not.  Modern systems can recover from such an event,
but nothing is totally bulletproof to such an event.

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