Is it Ok to remove old .plist files remaining from deleted software?

Hi Folks,
I'd appreciate some thoughts from some of you experts here.
I''m doing some house cleaning of my OSX Mountain Lion and have found some old .plist files in my preferences folder, that remain after the software was removed long ago. For Example, I found some old Color Munki files remaining from when I tried a Color Munki unit for a week or so and sent it back, unstalling alll of its associated software.
Any harm in throwing these in the trash and emptying it?
And I guess on a more general basis can old files left over from deleted software be removed as well?
Many thanks

Installing 3rd party apps can affect permissions on system files and folders. Running Repair permissions ensures all system files permissions are set to what they should be as listed in the BOM, stored in Library/Receipts.
If you can provide me one argument as to why that isn't worth doing, I might let you keep that chicken's head...

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