Is there a maximum file size that can be converted to pdf

I have a 448mb tiff that I want to convert to a pdf. However, Acrobat gives me the error that the file is damaged or there is some other problem. Photoshop CS5 opens the file with no problem. It won't convert it to a PDF either.
The tiff is at 200 resolution. If I reduce it to 60 it will convert.
Am I trying to do something that can't be done?

Open in PS and print to the Adobe PDF printer. However, a 448MB TIFF seems huge. At 200 dpi and 24 bit color (millions of colors) that leaves you with a 61inX61in graphic. Even at 600dpi, that is 20X20.
For us to help you, please indicate exactly how you are trying to convert from PhotoShop. For Acrobat, are you trying to open the TIFF in Acrobat directly? Is the TIFF a single sheet, or multiple sheet? There are a lot of unanswered questions for us.
One of the limitations on file size is the size of the temporary PS file that is created in the PDF creation process. This PS file is created in the TEMP folder that is limited by MS. So you might try emptying the TEMP folder.

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