Is there a way to reduce the size of a final PDF created for print when saving a file?

Is there a way to reduce the size of a final PDF created for print when saving in any software (especially illustrator)? I don't want any quality to decrease at the same time. Thanks!

Personally I would avoid optimizing the PDF's via Adobe Acrobat Pro unless you understand what you are removing from the PDF; having said that, it is the most effective way to reduce the file-size in the right hands.
If I am sending out layouts for commercial print I change my default Print / Export setting from Standard to PDF/A-1b:2005 (CMYK). This will resolve a lot of common print problems for print-ready documents and it should embed your fonts and flatten transparencies etc.
If your document is still too large you run an Audit Space Usage using Adobe Acrobat Pro. In the left pane enable 'Content' and then hit the button in the top left corner of the Content Pane and choose Audit Space Usage.

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