ISE 1.3 - Multiple ADs and time zone

Hi all,
I have a question regarding time zone settings, AD interaction and ISE PSN.
Assuming the following deployment:
- ISE distributed deployment with 3
- Each PSN is joined to a AD at a specific site (example: one in USA, one in Europe, one in Asia)
If the DCs at each site have different clocks (same UTC time source, but different time zone) I'll probably run into issues, right?
Because:
First fact:
Set correct time and timezone. Kerberos needs to be within 5 mins of the DCs you use
 (Source: Cisco Live Breakout BRKSEC-2132)
Second fact:
Also, it is important to have all the nodes in a single ISE deployment configured to the same
time zone. If you have ISE nodes located in different geographical locations or time zones, you should
use a global time zone such as UTC on all the ISE nodes.
 (Source: ISE 1.3 admin guide)
So the first recommendation is, that the ISE PSN has the same clock as the local DC - on the other hand the time zones in one distributed deployment should be the same on all nodes.
What to do?
Big thanks in advance!
Johannes

Not yet - In my lab environment I'm not having a multi-tier CA (and I'm not very good when it comes to Microsoft Active-Directory stuff :) )
Edit:
I did one very limited test in my testlab. In my testlab I'm having one DC and two ISE appliances.
Test1: I removed the AD join of the ISE appliances. The ISEs are configured for CET and I reconfigured the time zone of the DCs to UTC-7:00.
ISE and DC clocks are correct (synced against NTP), but the absolute time is different due to different time zones.
Then I joined the ISEs again - and it worked.
Test2: I removed the AD join of the ISE appliances. The ISEs are configured for CET and I configured an incorrect static time to the DCs (some weird time).
ISE join won't work
Error Description: Clock skew detected with active directory server
Support Details...
Error Name: LW_ERROR_CLOCK_SKEW
Error Code: 40087
Perfect - different time zones are obviously ok...

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