ISql*Plus works well, but sqlplus throws ORA-12560. Why?

I installed Oracle DB 10.2.0.1 on Windows XP. After the installation, everything works like clockwork. ... well, until I installed Oracle Application server 10.1.2.0.2.
For the most part, it still works fine. But now, whenever I run sqlplus from command line, I get ORA-12560: TNS:protocol adapter error. I can still connect using the same login from iSql*Plus without any problem. Why?
Now I'm supposed to cd into a directory, fire off sqlplus and run a sql script. How do I do this in iSql*Plus?
Any help? Thanks,
-M

Thanks for the replies. I got the idea. I need to set
those variables myself, although I personally think
the installer should take care of that during
installation.
Now, out of curiosity, why did iSql*Plus never have
the problem even though I didn't have any those
variables set in my environment?No idea why those aren't set automatically, but they aren't, as you found out. :)
iSQL*Plus is a web based service, and I believe it uses JDBC, not straight OCI calls.

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