Issue sending e-mails to certain domain

I'm having an issue sending e-mails to domain capitaliii.com from my Ironport.  I see the following message in the Ironport log.
"DNS Temporary Failure capitaliii.com MX - unable to reach nameserver on any valid IP"
When I issue a nslookup on the MX record from the Ironport, I get the below message.
Temporary query error:  "unable to reach nameserver on any valid IP" looking up A record for "capitaliii.com" to nameserver
ns3.digipark.com
I can however do a successful a successful nslookup from my workstation.  See the results below.  Any ideas?  I've done
a flushdns on the Ironport to no avail.
Non-authoritative answer:capitaliii.com  MX preference = 10, mail exchanger = mail1.digipark.commail1.digipark.com      internet address = 64.111.26.141

Hello Doug,
check if your firewall in front of the IronPort appliance allows TCP for DNS on port 53.  The query results I get are close to the 512 byte limit, where DNS switches from UDP to TCP:
cisco$  dig mx capitaliii.com +trace
; <<>> DiG 9.6-ESV-R4-P3 <<>> mx capitaliii.com +trace
;; global options: +cmd
.                       274955  IN      NS      f.root-servers.net.
.                       274955  IN      NS      g.root-servers.net.
.                       274955  IN      NS      h.root-servers.net.
.                       274955  IN      NS      i.root-servers.net.
.                       274955  IN      NS      j.root-servers.net.
.                       274955  IN      NS      k.root-servers.net.
.                       274955  IN      NS      l.root-servers.net.
.                       274955  IN      NS      m.root-servers.net.
.                       274955  IN      NS      a.root-servers.net.
.                       274955  IN      NS      b.root-servers.net.
.                       274955  IN      NS      c.root-servers.net.
.                       274955  IN      NS      d.root-servers.net.
.                       274955  IN      NS      e.root-servers.net.
;; Received 260 bytes from xxx.xxx.xxx.xxx in 189 ms
com.                    172800  IN      NS      a.gtld-servers.net.
com.                    172800  IN      NS      b.gtld-servers.net.
com.                    172800  IN      NS      c.gtld-servers.net.
com.                    172800  IN      NS      d.gtld-servers.net.
com.                    172800  IN      NS      e.gtld-servers.net.
com.                    172800  IN      NS      f.gtld-servers.net.
com.                    172800  IN      NS      g.gtld-servers.net.
com.                    172800  IN      NS      h.gtld-servers.net.
com.                    172800  IN      NS      i.gtld-servers.net.
com.                    172800  IN      NS      j.gtld-servers.net.
com.                    172800  IN      NS      k.gtld-servers.net.
com.                    172800  IN      NS      l.gtld-servers.net.
com.                    172800  IN      NS      m.gtld-servers.net.
;; Received 504 bytes from 198.41.0.4#53(a.root-servers.net) in 23 ms
capitaliii.com.         172800  IN      NS      ns4.digipark.com.
capitaliii.com.         172800  IN      NS      ns3.digipark.com.
;; Received 109 bytes from 192.55.83.30#53(m.gtld-servers.net) in 50 ms
capitaliii.com.         86400   IN      MX      10 mail1.digipark.com.
capitaliii.com.         86400   IN      NS      ns3.digipark.com.
capitaliii.com.         86400   IN      NS      ns4.digipark.com.
;; Received 147 bytes from 64.111.26.135#53(ns4.digipark.com) in 148 ms
Hope that helps,
Andreas

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