ITunes 10.5.3 update failes to install

Window 7 64-bit currently running iTunes10.5.2.11
Every time i try and run the update for iTunes 10.5.3.3 x64 installer, it goes so far as to ask where to install (yes I ran the download manually after the automatic update failed a few times).
Each time it failes almost immeadiately with the error:
"The installer encountered errors before iTunes could be configured.
Errors occured during installation. Your system has not been modified.
Please run the installer again, or click Finish to exit."
I noticed a few things.
a) The version number in about iTunes does not show the x64 after it like the splash screen for 10.5.3
b) My iTunes is installed in Program Files (x86) which is where 32 bit versions generally get installed.
So do I currently have the 32 bit version installed and the auto installer is tring to update it to the 64 bit and that is why it fails?
I've tried run the install to Program Files instead of Program Files (x86). Fails just the same. Do I need to uninstall iTunes and reinstall to get the update to work?
Or is the 10.5.3 install just borked?

Try downloading the package for new installs. the update package failed, but the new install package worked for me without any trouble.
History:
I began this trouble shooting exercise by selecting Download Only through the Apple Update applet. Running the msi manually did not resolve the problem. In fact, it was more frustrating because the download package would disappear after running even though it failed, and I had to download it again. "Cleanup" I suppose. <frown>
I followed advice to remove the Apple Software Update program, reboot and re-run the msi. That did not resolve the failure.
I then followed advice to set permissions for Administrators on registry key HKLM\Software\Micorosoft\Windows\CurrentVersion\Installer\UserData\S-1-5-18\Com ponents
then reboot and run the update msi again. This also did not resolve the failure.
I downloaded the installer from the Apple download site as though it were a fresh install, and - voila! - it installed correctly and all content and settings were preserved. Hopefully that is all that is needed, not the steps above. Let me know! http://www.apple.com/itunes/download/

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