ITunes 10.6.3 slow to respond

After upgrading to iTunes 10.6.3 I have a response issue. When selecting a song and clicking Play it takes a second or so to begin playing. The same delay occurs when "skipping" through a playing track. I've backuped my system, reformatted the drive and reinstalled Lion. The issue presists. I can't seem to find anything on this on other forums and my local Apple Reseller says it is bad audio files.
My iTunes media is on an external drive. When connected to a Mac Mini running Snow Leopard and iTunes 10.5 I get immediate responses. Same thing when I connect the iTunes media to my MBP which is running 10.7.4 and iTunes 10.6.3. This would seem to eliminate the media as being corrupted.
Anyone else having this problem?

I hvae the EXACT same issue
I built a new computer which is EXTREMELY fast overclocked i7 ect and.. ITUNES DOESNT WORK
I click on itunes which ive uninstalled and reinstalled and reset the winsock AND seen if there were any errors AAAAAAND ive check the Hkey to make sure bonjur was the only one in there which it is and all that happens is my cpu goes to 25% and i cant do anything except go into the task manager and close it! ANYTHING with itunes (everything else is premium speed).
what do i do
windows 7 64 bit

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I am facing issues after upgrading the mac book pro 2011 late model to osx lion 10.8.3 .
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851 mdworker     0.0 00:00.11 3    1    55   67    1640K 23M    6168K 51M    2416M 851 137 sleeping 501 2204     212     787       295       2762
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Try this:
Reinstalling Lion/Mountain Lion Without Erasing the Drive
Boot to the Recovery HD: Restart the computer and after the chime press and hold down the COMMAND and R keys until the menu screen appears. Alternatively, restart the computer and after the chime press and hold down the OPTION key until the boot manager screen appears. Select the Recovery HD and click on the downward pointing arrow button.
Repair the Hard Drive and Permissions: Upon startup select Disk Utility from the main menu. Repair the Hard Drive and Permissions as follows.
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reset all settings
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settings- wifi- click network name- enter password - join
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