ITunes 10 will not connect to Store, let me sign in, check for updates on Windows Vista 32 bit.

Has anyone had trouble connecting to the iTunes Store while using Itunes 10 for PC?
I cannot check for updates, sign in, or connect to the store so all my app downloads must be done from my device.
Using:
Windows Vista 32-bit.
Cox McAfee anti-virus/firewall.

Many thanks.
With those symptoms, I'd try the following document:
Apple software on Windows: May see performance issues and blank iTunes Store
(If there's a SpeedBit LSP showing up in Autoruns, it's usually best to just uninstall your SpeedBit Video Accelerator.)

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