ITunes becomes 'not responding' within seconds of running

I have installed the latest version of iTunes but it won't run without crashing and becoming 'not responding'.  I can only kill it from Task Manager.  Initially I thought it was due to the Determining Gapless Playback Information sequence failing, so I moved my iTunes database into another folder imagining that rescanning my library and creating a new one would solve the issue.  However when running, iTunes asks to scan my system for music, finds a few tracks then crashes again.
What can I do?
PC running Win 7
Music stored on NAS connected to Wifi Router
iPhone 4S

An update:
I found an article which suggested running iTunes in 'Safe Mode' to disable plug-ins.  I don't recall installing any plug-ins but I did this nonetheless.  I'm happy to report iTunes ran and got through the Determining Gapless Playback process.
I searched in the places where the article suggested the plug-ins were stored and did not find any files (though I did find the folders).  I have got 'Show hidden folders and files' selected.
What else can I do, other than running iTunes in Safe Mode every time?

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