ITunes cannot open files in the "MP3 Audio File" format

Lately I've been getting this error that iTunes can't open MP3 files. It happens when I try to double click on an MP3, however, if I click and drag the MP3 into my iTunes library it opens fine. Not a huge problem....just a nuisance.
Running iTunes 10.0.1

I suddenly have this same problem with MacOS 10.6.7 and iTunes 10.2.2. Clicking on a tune in a folder gets the prompt "The document xxxx.mp3 could not be opened. iTunes cannot open files in the MP3 audio format."
Dragging the tune into iTunes will open it, so there's no problem with it being a "trouble file" that needs validating with some external app. I believe this is a new glitch that came with iTunes 10.2.2. It's workable but quite irritating when trying to manage an iTunes library that includes 28,000-plus songs.

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    Okay. Let's try newer versions of the instructions, then.
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