"iTunes could not connect to this iPhone. This device is no longer connected."

This is the third time in a week I've had iTunes get stuck with a message saying "iTunes could not connect to this iPhone. This device is no longer connected.".
I keep hitting "OK", but the message continues.   Force quitting and then restarting iTunes does nothing.   Force quitting and turning off my iPhone did nothing.   I think I need to shut down my iPhone and then reboot.   That's what I did the other two times.
Is there a permanent fix for this problem?

It's an iTunes 12 bug... Not sure who's responsible for usbmuxd at Apple, but they should be fired! This was extensively discussed and worked out here: itunes 12 will not recognize iphone
All credit to oskapt, who's post detailed the entire issue. The short version is a recent version of usbmuxd has a programming error that leads it to never close any connection. At the same time, it's constantly making new connections too. The end result is this background process actually hits the built-in UNIX limit on open connections by a single process (to prevent bugs like this from ultimately crashing an entire computer), and is blocked by design from functioning after that point. Once usbmuxd fails, iTunes can't see your iOS devices.
The fix is to quit usbmuxd, either via Activity Monitor or Terminal. It will automatically relaunch, and work again until it hits the limit. That thread has several suggestions for automated scripts to run every 24-48 hours to prevent this. Hopefully an OS X or iTunes update will fix this, but it's been known for several months so far without any action on Apple's part. You'd think they'd want to make their flagship products actually "just work" together.
Then again, quality control at Apple has been going downhill for quite some time and is now getting pretty embarrassing. See this (somewhat off-the-cuff and hyperbolic) post by Marco Arment or this (more reasonable) post by Craig Hockenberry for the take of two third-party developers concerned for the drop in Apple's software quality lately.
Hope this fixes it!

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