ITunes freezes after a sync and then clicking to disconnect

My iTunes is behaving very strangely lately.  After I've done a sync (with my iPod Nano 6th gen), which works fine, and then click the disconnect button iTunes locks-up.  It displays the spinning beach ball but never stops and I can't quit iTunes without a forced quit.  On top of that, if I try to restart my Mac, my computer will not restart/shut-down etc. without a hard stop (pressing the on-button until it turns off).
In addition, just this week I been getting a message that say "The selected movie won't play on your display", "This movie can be played only on displays that support HDCP (High-bandwidth Digital Content Protection)".   This may be an unrelated issue but if you have any thoughts let me know.
Help!  Any ideas as to what this may be?  I've already tried to reinstall iTunes again (latest version).  Thanks in advance for any help.
Mac: Mac Pro (early 2009) 2.93 GHz Quad-Core Intel Xeon
8 Gb memory
Mac OS 10.7.2
ATI Radeon HD 5870
Apple Cinema 30" display
Thanks,
Marty

Hi sidneyboating,
Thanks for visiting Apple Support Communities.
You may want to use these steps to verify you have a good connection to the iTunes Store:
Can't connect to the iTunes Store
http://support.apple.com/kb/ts1368
All the best,
Jeremy

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