ITunes freezes MacBook Pro

Recently, my MacBook Pro (early 2010) started locking up to where only the mouse moves, but nothing else works.  The culprit seems to be iTunes, as the freezes tend to occur after I launch iTunes (although not the first launch - more on this).  After several hours of normal operation, popping into iTunes freezes things up.  I have found that by hard rebooting into safe mode, launching iTunes there and allowing it to load normally, then rebooting in "normal" mode lets things work for several hours.  Could it be something with my library?  It's on my local drive.  I ask about the library because in safe mode, that's always the first thing I see when launching iTunes, a dialog saying the library is loading.
Anyway, getting pretty frustrated, and wondering if I need to start reinstalling things...
Running OS X 10.7.5, iTunes 11.0.1 (12)
Thanks

Oh, and I remember more about how this started.  Recently, my battery died while using it - it went down to close to zero and hibernated, and it wouldn't come back out even when I plugged it in again, so I had to hold the power button to get it to boot up again.  Since then, iTunes has been doing its thing.

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    6/5/14 5:24:00.420 PM [0x0-0x12012].com.apple.Safari: CoreAnimation: rendering error 506
    6/5/14 5:24:00.423 PM [0x0-0x12012].com.apple.Safari: CoreAnimation: rendering error 506
    6/5/14 5:24:00.424 PM [0x0-0x12012].com.apple.Safari: CoreAnimation: rendering error 506
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    6/5/14 5:24:06.990 PM [0x0-0x12012].com.apple.Safari: CoreAnimation: rendering error 506
    6/5/14 5:24:07.007 PM [0x0-0x12012].com.apple.Safari: CoreAnimation: rendering error 506
    6/5/14 5:24:08.415 PM [0x0-0x12012].com.apple.Safari: CoreAnimation: rendering error 506
    6/5/14 5:24:14.206 PM sandboxd: ([197]) Safari Webpage P(197) deny iokit-open AppleGraphicsPolicyClient
    6/5/14 5:24:30.756 PM com.apple.SecurityServer: Session 100008 created
    6/5/14 5:24:30.802 PM mdworker: Unable to talk to lsboxd
    6/5/14 5:24:50.829 PM sandboxd: ([197]) Safari Webpage P(197) deny file-read-data /
    6/5/14 5:24:56.769 PM sandboxd: ([197]) Safari Webpage P(197) deny file-read-data /
    6/5/14 5:24:56.785 PM sandboxd: ([197]) Safari Webpage P(197) deny file-read-data /
    6/5/14 5:24:56.800 PM sandboxd: ([197]) Safari Webpage P(197) deny file-read-data /
    6/5/14 5:24:56.816 PM sandboxd: ([197]) Safari Webpage P(197) deny file-read-data /
    6/5/14 5:24:56.916 PM sandboxd: ([197]) Safari Webpage P(197) deny file-read-data /
    6/5/14 5:25:17.236 PM mds: Unable to talk to lsboxd
    6/5/14 5:25:33.332 PM mdworker: Unable to talk to lsboxd
    6/5/14 5:35:55.708 PM powerd: PMScheduleWakeEventChooseBest: m=0.00 s=0.00 a=0.00
    6/5/14 5:35:55.000 PM kernel: hibernate image path: /var/vm/sleepimage
    6/5/14 5:35:55.000 PM kernel: sizeof(IOHibernateImageHeader) == 512
    6/5/14 5:35:56.000 PM kernel: Opened file /var/vm/sleepimage, size 4294967296, partition base 0x0, maxio 400000 ssd 0
    6/5/14 5:35:56.000 PM kernel: hibernate image major 14, minor 0, blocksize 512, pollers 5
    6/5/14 5:35:56.000 PM kernel: hibernate_alloc_pages flags 00000000, gobbling 0 pages
    6/5/14 5:35:56.000 PM kernel: hibernate_setup(0) took 0 ms
    6/5/14 5:36:04.000 PM kernel: hibernate_page_list_setall start 0xffffff806a84d000, 0xffffff806a86d000
    6/5/14 5:36:04.000 PM kernel: hibernate_page_list_setall time: 177 ms
    6/5/14 5:36:04.000 PM kernel: pages 420187, wire 109195, act 62895, inact 970, spec 72, zf 0, throt 0, could discard act 56254 inact 37234 purgeable 5379 spec 148188
    6/5/14 5:36:04.000 PM kernel: hibernate_page_list_setall found pageCount 173132
    6/5/14 5:36:04.000 PM kernel: IOHibernatePollerOpen, ml_get_interrupts_enabled 0
    6/5/14 5:36:04.000 PM kernel: IOHibernatePollerOpen(0)
    6/5/14 5:36:04.000 PM kernel: writing 172798 pages
    6/5/14 5:36:04.000 PM kernel: encryptStart 2e720
    6/5/14 5:36:04.000 PM kernel: encryptEnd 8f15800
    6/5/14 5:36:04.000 PM kernel: image1Size 0xc1c7c00, encryptStart1 0x2e720, End1 0x8f15800
    6/5/14 5:36:04.000 PM kernel: encryptStart c1c7c00
    6/5/14 5:36:04.000 PM kernel: encryptEnd 12f42000
    6/5/14 5:36:04.000 PM kernel: PMStats: Hibernate write took 4086 ms
    6/5/14 5:36:04.000 PM kernel: all time: 4086 ms, comp bytes: 708325376 time: 718 ms 939 Mb/s, crypt bytes: 264639712 time: 618 ms 408 Mb/s,
    6/5/14 5:36:04.000 PM kernel: image 317988864, uncompressed 708325376 (172931), compressed 316371536 (44%), sum1 c3cbc1e6, sum2 6295c0f
    6/5/14 5:36:04.000 PM kernel: wired_pages_encrypted 65406, wired_pages_clear 43588, dirty_pages_encrypted 63937
    6/5/14 5:36:04.000 PM kernel: hibernate_write_image done(0)
    6/5/14 5:36:04.000 PM kernel: sleep
    6/5/14 5:36:32.000 PM kernel: Wake reason: EHC1
    6/5/14 5:36:32.000 PM kernel: Previous Sleep Cause: 5
    6/5/14 5:36:32.000 PM kernel: The USB device HubDevice (Port 1 of Hub at 0x1d000000) may have caused a wake by issuing a remote wakeup (2)
    6/5/14 5:36:32.000 PM kernel: wlEvent: en1 en1 Link DOWN virtIf = 0
    6/5/14 5:36:32.000 PM kernel: AirPort: Link Down on en1. Reason 8 (Disassociated because station leaving).
    6/5/14 5:36:32.000 PM kernel: en1: 802.11d country code set to 'X3'.
    6/5/14 5:36:32.000 PM kernel: en1: Supported channels 1 2 3 4 5 6 7 8 9 10 11 12 13 36 40 44 48 52 56 60 64 100 104 108 112 116 120 124 128 132 136 140
    6/5/14 5:36:32.000 PM kernel: The USB device HubDevice (Port 8 of Hub at 0x1d100000) may have caused a wake by issuing a remote wakeup (3)
    6/5/14 5:36:32.000 PM kernel: TBT W (1): 0 [x]
    6/5/14 5:36:32.000 PM kernel: The USB device Apple Internal Keyboard / Trackpad (Port 3 of Hub at 0x1d180000) may have caused a wake by issuing a remote wakeup (3)
    6/5/14 5:36:32.000 PM kernel: HID tickle 200 ms
    6/5/14 5:36:33.000 PM kernel: en1: 802.11d country code set to 'GR'.
    6/5/14 5:36:33.000 PM kernel: en1: Supported channels 1 2 3 4 5 6 7 8 9 10 11 12 13 36 40 44 48 52 56 60 64 100 104 108 112 116 120 124 128 132 136 140
    6/5/14 5:36:33.000 PM kernel: MacAuthEvent en1   Auth result for: 14:60:80:82:7f:04  MAC AUTH succeeded
    6/5/14 5:36:33.000 PM kernel: wlEvent: en1 en1 Link UP virtIf = 0
    6/5/14 5:36:33.000 PM kernel: AirPort: Link Up on en1
    6/5/14 5:36:33.000 PM kernel: en1: BSSID changed to 14:60:80:82:7f:04
    6/5/14 5:36:33.000 PM kernel: AirPort: RSN handshake complete on en1
    6/5/14 5:36:35.219 PM airportd: _doAutoJoin: Already associated to “pithoprakta”. Bailing on auto-join.
    6/5/14 5:36:35.000 PM kernel: en1: BSSID changed to 14:60:80:82:7f:04
    6/5/14 5:37:01.000 PM kernel: MacAuthEvent en1   Auth result for: 14:60:80:82:7f:04  MAC AUTH succeeded
    6/5/14 5:37:01.000 PM kernel: wlEvent: en1 en1 Link UP virtIf = 0
    6/5/14 5:37:01.000 PM kernel: wl0: Roamed or switched channel, reason #8, bssid 14:60:80:82:7f:04
    6/5/14 5:37:01.000 PM kernel: en1: BSSID changed to 14:60:80:82:7f:04
    6/5/14 5:37:01.000 PM kernel: AirPort: RSN handshake complete on en1
    6/5/14 5:45:49.808 PM com.apple.SecurityServer: Session 100012 created
    6/5/14 5:45:50.700 PM sandboxd: ([261]) WebProcess(261) deny iokit-open AppleGraphicsPolicyClient
    6/5/14 5:46:40.244 PM com.apple.SecurityServer: Session 100007 created
    6/5/14 5:46:47.125 PM syspolicyd: loading GKE 5a871cdd-8f6e-4459-ab05-07f22489c3f5 (replacing nothing)
    6/5/14 5:59:46.603 PM com.apple.security.pboxd: kCGErrorIllegalArgument: CGSGetWindowTags: Invalid window 0x85
    6/5/14 5:59:46.603 PM com.apple.security.pboxd: kCGErrorFailure: Set a breakpoint @ CGErrorBreakpoint() to catch errors as they are logged.
    6/5/14 5:59:46.603 PM com.apple.security.pboxd: kCGErrorIllegalArgument: CGSSetHideOnDeact: error getting window tags
    6/5/14 5:59:46.628 PM com.apple.security.pboxd: kCGErrorIllegalArgument: CGSCopyWindowColorSpace: Invalid window 0x85

    This is not due to any kind of malware. Neither is Safari opening an SQLite database a concern... Webkit has direct support for SQLite.
    Since the problem persisted across a clean reinstall, it has to be a hardware issue. Note that Apple Hardware Test results can only be relied on if they are positive - ie, if a hardware problem is detected, you can be sure that hardware problem exists. On the other hand, if nothing is found, that really doesn't mean much. It just means that of the things Apple Hardware Test is capable of checking for, none are failing in a way that Apple Hardware Test can detect, and it tells you nothing at all about the things it's not capable of checking.
    If I had to guess, I'd say it's likely your hard drive is dying. However, that's just a guess. You should have an Apple tech take a look for you.

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