ITunes freezing with error -50, -3259 and 9006

Okay, so I have had a problem with iTunes freezing in relation to downloading Podcasts since around version 8.  After updating to 10.2.2 on 10.6.7, iTunes has turned into one big fail.  Downloading anything produces any of the following error codes: -50. 3259 and 9006 after about 30 seconds.  After any error code is displayed, a few seconds later iTunes freezes with the pinwheel of death and no matter how long I leave it, I end up having to restart using my computer's power button.  After 2-3 restarts like this, the iTunes library is corrupted and the app freezes while loading the library.  During this library freeze, the drive where my iTunes library is stored is ejected.  This happens on both internal and external drives.
Here is what I have done thus far:
Uninstalled iTunes completely.
Created a new user account and installed iTunes 10.2.2 to that account.
Added various media.
I have absolutely NO problems with iTunes until I download a podcast or something from iTunes U.  Then, the issues occur and I cannot seem to get rid of them until I unistall completely and reinstall to a new user account. 
I would like to be able to use iTunes WITH podcasts and iTunes U on my main user account without the freezing.  Any suggestions?

I seem to have fixed my own problem.  I just thought I'd post my solution since I read posts from many, many people having similar issues.  So hopefully, this helps someone!
I found a file in /Library/Preferences called com.apple.pcast_integration.plist; the file text included QuickTimePro and Podcast Producer Export in its strings.  Deleting the file solved my problem.  I went from my main user account freezing constantly and throwing up errors to working 100% smoothly with just deleting that one file.  I cannot believe this simple action solved a problem I've been having for so long!
I do not understand how this file is being referred to in downloading podcasts.  I have tried everything, even loading and playing all types of media from old libraries I thought were corrupt, but cannot seem to make iTunes or Quicktime recreate the file...nor can I find anyone else having trouble due to this file.  Could it be a remnant from an old installation, or something that somehow deployed along with a podcast?  If anyone can tell me more about com.apple.pcast_integration.plist, I would appreciate it.  And let me know if removing it helps you!

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