ITunes is locking up during sync of iphone and ipad during backup

When I try to sync either my iPad or my iPhone 3GS, iTunes is locking up during the backup stage of the sync.  This started two days ago.

Thanks whatheck, that worked!  I confirm that my antivirus (ESET Smart Security) was interfeering:
I disabled ESET and synched - it worked!
Then I also backed it up manually, and that worked also (30 seconds).
Then I re-enabled Eset and backed up again... it still worked...
BUT then I Synched again, and it failed!  Had to kill iTunes and the applemobiledeviceservice with taskmgr.
So I turned off realtime file system protection in Eset, and after restarting iTunes (with 3gs still connected), Itunes said "Verifying PaulW's iPhone" for a couple minutes. 
- Then it synched fine (couple minutes at most - got a new podcast). 
- Then I backed up again manually which worked (10 seconds!).
- Then I synched again, no problem.
Note that AppleMobileDeviceService.exe is still using 50% cpu when sitting there doing nothing, even with iphone not connected.  Have to kill it manually (in task manager - processes) or cpu fan runs constantly.
FYI: my ESET is a couple weeks out of date (subscription expired) will have to update it...

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