Itunes never opens

HELP ME! SOS
This first happened about a month ago, I updated my itunes, then after I restarted my computer as I was instructed. Then the next time I went to open my itunes I get a window that say " you must restart your system for the configuration changes made to iTunes to take effect. Click yes to restart now or No if you plan to manually restart later." So I restarted my computer again, I went to open my itunes after restarting and I got the same window so I uninstalled the itunes program an then re-installed it. After installation was complete I ran the program and it worked, I used my computer then shut down for the night. Well the next time I tried to open my itunes and the window popped up again! Does anyone know what wrong
Thanks
m.medina_81

Update:
https://discussions.apple.com/message/22490926#22490926
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Try to connect in recovery mode, explained in this article:
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Before that, back up your device, explained here:
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ITunes never opens in Vista 64 bit help

Im running a Windows Vista 64 bit laptop. I tried installing iTunes several times. After sever times I finally got it to install.
But when I went to run it nothing happend. Nothing at all. I hooked up my iPod and still nothing.
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Update:
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Hi, I've recently bought an iPad2 and can't get connected with AppStore or iTunes, when I tap on these icons a grey page pops up saying is loading but never opens the page, no failure message is displayed, it just keep saying is loading. Apparently it is

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ITunes wont open - Quicktime issue

Ive tryed to reinstall itunes at least half a dozen times now and nothing will fix this issue. If i try to open itunes, the process (in task manager) starts but gets to about 38000K then nothing, never opens no matter how long i wait. Im unable to end this process either, so it just sits there taking up memory. Following the advice of someone else in another thread i tryed changing the compatability of quicktime and itunes to windows 2000 and this gave me the error message that "quicktime is required to run itunes" despite the fact that i do have it installed. Reinstalling both itunes and quicktime have no effect on the problem, does anyone have any ideas?

Hello BaconSquishy.
First thing I would do is turn compatibility mode off if you have it on for iTunes and Quicktime. As this will not really fix anything except under rare and special conditions.
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Uninstall the following Apple Applications in the following order.
Launch Control Panel and open Add/Remove Programs or Programs and features if you have Vista.
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http://www.apple.com/quicktime/download/
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http://support.apple.com/kb/HT1926?viewlocale=en_US

When connected via USB, my Ipod Classic 160GB mounts as a disc drive, then changes to a white drive. When iTunes automatically opens, it crashes trying to mount and/ or sync. When it times out, my only choice is to restore, but that doesn't fix problem.

I'm running OS 10.6.8 on my 3.06 GHz iMac Intel Core 2 Duo.   I recently upgraded to iTunes 10.5.2. I'm not sure when the trouble started but I attempted a restore when the iPod would not play correctly. It would start to play a file and get stuck on 0 seconds. If I put the iPod on shufle, it will stall on 0 seconds for 15 seconds or so and then move on to the next track and stall again and so on.   Seemingly randomly, it will play a few tracks but eventually start skipping again. This will continue until the battery is depleted which is fairly quick since the drive is constantly spinning.
My 160GB iPod Classic after restore attempts now is up to date with 2.0.4. and of course, nothing works as it should and I would say the skipping issue is worse than ever.
When I connect with any of three USB connectors, the iPod mounts to the desktop as a grey/silver disk drive picon exactly like the Macintosh HD picon.   Then Finder will stall for a few minutes- spinning pinwheel. Somehow, the dock is never affected and I am able to open other applications like Safari or tab through open windows- just no action on the desktop. Eventually, iTunes automatically opens and Finder becomes responsive again. At this point the grey drive picon on the desktop becomes a white drive mount picon, but the iPod does not mount in iTunes, yet. At some point, the iPod attempts to sync, iTunes crashes with the spinning pinwheel and eventually times out and I am prompted to restore the iPod again. Once restored, the iPod properly mounts under devices in iTunes and, as I have done this several times, even occasionally changes to the regular iPod picon on the desktop.
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one more detail, after a restore, when I attempt to reload music to the ipod, if I try and move, say, 20 files, the transfer seems to work as it should but then stalls on the last file. Eventually, the status will change to "Updates Files on (my ipod)" a and suggests the iPod is syncing even though I have the auto sync feature turned off.
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