ITunes not opening when iPhone connected

Hi
My iTunes used to open and start syncing immediately I connected my iPhone - now it does not.
I've made sure the 'open iTunes when this iPhone is connected' box is ticked, switched off the iPhone and restarted it, restarted my MacBook, reset the sync history, deleted podcasts, restored the iPhone - nothing works.
Is this an iPhone OS 4.1 issue?
I'm running an 3GS iPhone with 4.1, iTunes vers. 10, on a MacBook OS X 10.5.8

I'm having the same issue. There is an "iphone assistant" walk-through page I've gone through but the steps ave not seemed to work for me. I deleted and reinstalled the latest iTunes, but when I plug in... nothing. The most I get is when my iphone is off and I plug in to my mac, it will turn on. No charge.

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