ITunes not working after 10.5.2 update, Need help!!!

After i updated to leopard.2 (10.5.2) whenever i try to open itunes this message apperars:
+The iTunes Library file is locked, on a locked disk, or you do not have write permissions for this file.+
so i cant use iTunes, iv tried changing the permissions with about everything having to do with iTunes and i changed the permissions on the Hard drive, and iv also repaired disk permissions, can anyone help me please?

Well it's been a few days & now my keyboard is acting up again. I'm working away when it becomes unresponsive. Sometimes it gets stuck like I'm pressing down on the track pad & it just draws that white box. I then have to restart my computer. SO All is not yet well. I saw other posts regarding similar issues & no I don't have any 3rd party keyboard plug-ins. Please read my first post for a complete breakdown on what's going on.
Thanks

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