ITunes on Mac won't open after update to 10.6.

I update  to iTunes 10.6 on Mac with 10.7.3.  Now iTunes won't open, it appears for a split second and then an error message saying iTunes has unexpectedly quit Don't Restore Windows or Restore Windows.  But you can't get either error prompt to respond.  Any help would be greatly apreciated.
Bengie

what if the disk image is on an attached FireWire Drive?
there is no OS on that drive, so I can't repair permissions.
I have two disk images on it: one opens fine, the other I get "no mountable file systems"
It opened just fine a few weeks ago
??

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