Itunes opens with error -50

Itunes opens with error -50 on my Mac. Once open signing in causes error 5002. Signing in from App store just fails. My Mac pc does not appear to be registered anymore and I can't sign in. On screen Support buttons don't connect so can't contact support online. Tried all the work arounds in discussions but no joy. Even tried deleting itunes to start agin but you can do that apparently. For one work around I Signed in through Safari to change payment details but payment option was not displayed. Getting really p'd off.  All is ok on my iphone/ipad etc but not my main pc. Any printable suggestions appreciated.

Found a fix that worked, didnt even need to refresh the network settings
Click the Finder icon in the Dock.
Choose Go to Folder from the Go menu.
Type:  /Library/Preferences/SystemConfiguration
Click Go.
In the Finder window, locate the file named "NetworkInterfaces.plist" and drag this file to the Trash.
Restart your computer.
Once your computer has restarted, you will not be able to connect to the Internet. You will need to refresh your network settings to be able to connect again:
Choose System Preferences from the Apple () menu.
Choose Network from the View menu.
If you're using Mac OS X v10.4, choose New Location from the Locations menu.
Click Apply Now at the bottom right.
If your network connection requires any special settings, you will need to put them back in at this point. You would have received these from your ISP or network administrator.

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