ITunes playback corrupted after FW 800 drive attached

I suspect this problem is more of a hardware issue than a software issue. But let me describe the problem.
I use iTunes to play mp3 recordings from my Mac Pro desktop with the output through a FW audio device (M-Audio Profire 610). Everything works fine until I attach an external My Passport hard drive connected via FW 800 cable to the computer.   As soon as this drive is connected there is immediate static and disruption of the itune playback that gets progressively worse until there is nothing but noise.  Disconnecting the external hard drive does not remedy the situation.  Neither does restarting iTunes.
The only way to fix the problem is to restart the computer.
Does anyone have any ideas what is happening?  The computer is offsite.  But when I have time to do some troubleshooting I will try connecting the hard drive with a different FW 800 cable or try connecting with its usb connector.  I will also try a different FW 800 device to see if the problem is repeated with a different drive.
John
Edit:  Additional information.  When I attach this firewire drive to my home computer running iTunes this problem does not occur.  It is only with the offsite problematic computer. However, I am not using a FW audio output device on my home computer.
John
Message was edited by: John Baughman

If Aperature is working okay, then there may be no need to reinstall it.
I doubt reinstalling it (or anything else) will delete any preferences. Maybe sone obscure 3rd party apps will write over prefs when reinstalling but I have never heard of any Apple applications deleting prefs when reinstalling.
Reinstalling iTunes will not affect anything. All preferences will be as they were.

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