ITunes stalls machine off and on after 10.6.8 Update

iMac i5 10.6.6 installed everything running great, upgraded to 10.6.8, iTunes (10.5) now locks the whole machine up then releases for a brief moment the locks again, this continues until quitting iTunes (10.5),  have noted in the activity viewer, disk access spikes into the red in conjunction with lockups, CPU normal.
Created a new library with 1 track in it to eliminate content.
This affects all user profiles and 1 created to test.
Have run latest tech tools all hardware cleared.
Disk Warrior run, all faults cleared, no change.
Did and archive and install with original 10.6.6 disk (not called this anymore but same affect) problem goes away, upgrade to 10.6.8 problem returns?
Have uninstalled iTunes 10.5 with app cleaner and gone back to previous versions of iTunes, no change.
Note: run with extensions off but no audio hardware available to playback and test.
Note 10.6.6 - 10.6.8 update is the combined update using Software Update, I have also downloaded this update and ran this way also. No Joy!
Note: Cannot update to Lion, mate lives rural and Apple have not bothered to write 64bit drivers for Apple USB dialup modem.
Any suggestions other than full format and rebuild?

Apple replaced the logic board under warranty and this resolved the issue, audio fault of some kind..

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