ITunes stops responding immediately after opening

My iTunes stops responding immediately after opening and even force-quit doesn't do.
Baically it freezes between pressing it and opening the window. In my large library, I can see that it loads it and then nothing more. The menu appears and then the wheel. Force quitting doesn't shut the program, no matter how I do it. It leaves the arrow and the only way is to restart the computer and start again.
I tried using another account, and it does the same. I tried with a new library. I tried with new prefs folder both on the user and on the Mac HD. I tried reinstalling iTunes. I even tried reinstalling the whole OS X - but nothing. The only thing is that after zapping PRAM it might work once or twice, but no more.
This is with iTunes 7.0.2, QuickTime 7.1.3 and OS 10.4.8
I don't know what else to do.
Any ideas?

I'm having the same problem. It started recently - maybe about two weeks ago - and occasionally when I launch iTunes it just freezes. I can't force quit it completely - it still shows in the Dock as though it's running, though it's not present in Activity Monitor.
Curiously, I've also had a couple of kernel panics when clicking iTunes buttons in the past week. I don't recall any system update that might have affected either iTunes or QuickTime, so I'm stumped... The only way to get iTunes back is to log out or restart.
Kirk

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